Drexel University College of Medicine

Perioperative Genomics

This is a very hot field currently due to the recent emphasis on precision medicine. We are trying to identify some new genomic alterations and refine currently-known genomic changes which are potentially highly predictive of postoperative adverse events in highly phenotypical patient population. By doing this we anticipate we can lower the perioperative adverse events to the lowest possible.

Included in the perioperative genomics is a focus on gene expressional changes induced by cardioactive drugs in cultured cardiomyocytes: We use rat cardiomyocytes cell line for this project. We investigate the changes in gene expression in cardiomyocytes after exposure of cardiomyocytes to various cardioactive medications, and potentially correlate the gene expressional changes with clinical outcomes. We adopt molecular biology techniques and microarray technology for this project.

The Expanded Use of Near Infrared Spectroscopy in Anesthesiology

In collaboration with the college of biomedical engineering we are attempting to develop a physiologic monitor for anesthetic depth. NIRS is unique in that a direct measure of regional blood flow and oxygen consumption can occur. This is much different than indirect measures currently utilized. This provides a more “real time” assessment of the depth of anesthesia for patients. In addition, the same changes in regional blood flow is under investigation as a predictor of those patients who are most at risk for the development of chronic post-surgical pain.

The Effect of Volatile Anesthetic Agents on Neonatal Brain Tissue

We currently investigate the potential changes in the brains of neonates exposed to volatile anesthetic agents. We utilize human brain tissue and explore the potential changes in the cytoskeleton that may be responsible for the negative impact of volatile anesthetic agents. In addition, we are considering different mechanisms of action of the volatile anesthetic agents and hope to generate information that contributes to the discovery of the mechansims.

Pain Research

Pain research focuses on several different areas. IV Ibuprofen Study for Acute Perioperative Pain: A single-center, randomized open label trial to compare the safety and efficacy of intravenous ibuprofen versus intravenous ibuprofen plus intravenous acetaminophen in total knee or hip arthroplasty surgeries. This study focuses on the multimodal use of various analgesic to control pain preoperatively. OVERSUSE Study: Overuse of over the counter pain medication products a survey study. This study is evaluating the risk of over the counter medication for pain to determine the usage and overuse of these medications. Nerve Ablation by Cooled Radiofrequency Compared to Corticosteroid Injection for Management of Knee Pain. This study evaluates the efficacy of cooled radio frequency ablation on treating osteoarthritis. This is collaborative national trial involving multiple pain center throughout the United States. Prospective, observational study evaluating the ability of clinical factors to predict interventional treatment outcomes for low back pain. This is a collaborative study with Johns Hopkins on looking at predictors for outcomes for pain treatment

Improvement of Cormack-Lehane Grades and POGO Scores Via Video Laryngoscopy Versus Direct Laryngoscopy in Morbidly Obese Patients Undergoing Elective Weight Loss Surgery

Morbidly obese patients can have challenging airways. Video laryngoscopies have made most airway challenge surmountable. This study will evaluate this theory in the morbidly obese using C Mac video laryngoscopes.