Brigham and Women’s Hospital
Center for Experimental Therapeutics & Reperfusion Injury
Research in the Center for Experimental Therapeutics & Reperfusion Injury focuses on structural elucidation of endogenous molecules that activate the resolution of acute inflammation, organ protection and tissue regeneration. Our overall mission is “To identify novel mediators, pathways, and cellular targets critical in promoting resolution of inflammation and reperfusion tissue injury and their relation to human disease.” Our studies currently focus on structural elucidation of novel molecules and pathways that are pro-resolving and anti-inflammatory chemical signals and elucidating the pro-resolving mechanisms in ischemia reperfusion injury to demonstrate resolution-based pharmacology.
We elucidated several new families of lipid-derived, local-acting chemical mediators, coined the Resolvins and Protectins, and most recently Maresins, that stimulate resolution of inflammatory responses in diverse animal disease models. We also designed novel therapeutic approaches using these structures as biotemplates, their biosynthetic pathways and receptors. New therapeutic approaches built with the knowledge of these signaling pathways could be more potent, selective and better tolerated since they are based on structures naturally evolved in these processes. Several of these new designer therapeutics that stimulate resolution of inflammation have already been shown to be effective in humans in early stage clinical trials.
Funding: P01HL108801 - Carbon monoxide: novel opportunities for therapy; P01HL108801 - Lipid mediator metabolomics; P01GM095467 - Resolution mechanisms in acute inflammation: resolution pharmacology; P01GM095467 -Core A and Core B:SPM-Lipidomics & metabolomics; P01GM095467 - Project 1 : novel specialized pro-resolving lipid mediators; R01GM038765-31 – Blood cell lipoxygenase products—formation and action
PI: Charles N. Serhan, Ph.D, D.Sc.
Email: cserhan@bwh.harvard.edu
Web page: http://research.bwhanesthesia.org/research-groups/cetri
Lab video: https://bwhclinicalandresearchnews.org/2017/01/04/searching-for-answers-in-inflammation/
Selected Publications:
- Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 2012; 484:524-28.
- Norris PC, Libreros S, Chiang N, Serhan CN. A cluster of immunoresolvents links coagulation to innate host defense in human blood. Sci Signal. 2017; 10:eaan1471 (Epub Aug 1; doi: 10.1126/scisignal.aan1471).
- Dalli J, Chiang N, Serhan CN. Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med. 2015; 21:1071-75 (Epub 8/3/15; doi: 10.1038/nm.3911).
- Dalli J, Colas RA, Arnardottir H, Serhan CN. Vagal regulation of Group-3 innate lymphoid cells and the immunoresolvent PCTR1 controls infection resolution. Immunity 2017; 46:1-14 (Epub 2017 Jan 05; doi: 10.1016/j.immuni.2016.12.009).
- Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur B, Petasis NA, Chiang N, Serhan CN. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc Natl Acad Sci USA 2016; 113:12232-37 (doi: 10.1073/pnas.1607003113).
- Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014; 510:92-101.
- Spite M, Clària J, Serhan CN. Resolvins, specialized pro-resolving lipid mediators, and their potential roles in metabolic syndrome. Cell Metab. 2014; 19:21-36 (Epub Nov 13, 2013; 10.1016/j.cmet.2013.10.006 [doi]). Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014; 510:92-101.
- Spite M, Clària J, Serhan CN. Resolvins, specialized pro-resolving lipid mediators, and their potential roles in metabolic syndrome. Cell Metab. 2014; 19:21-36 (Epub Nov 13, 2013; 10.1016/j.cmet.2013.10.006 [doi]).
Clinical Pain Research Center
The clinical pain research center is a part of the Pain Management Center at Brigham & Women's Hospital / Harvard Medical School. The centers main research focus involves the biopsychosocial influences on the experience of chronic pain. This includes individual differences in pain responses, and the neurobiological mechanisms by which psychosocial processes shape those individual differences. Some of the current projects focus on the impact of negative emotions and cognitions (e.g., pain-related catastrophizing) on neuroendocrine and inflammatory responses to pain, the potential benefits of non-pharmacologic therapies for chronic pain (e.g., meditation, cognitive-behavioral therapy, yoga), central nervous system pain-modulatory processes, and functional connectivity of pain circuitry in the brain.
Several of our studies use functional neuroimaging techniques to assess the neurobiology of pain-related thoughts and emotions, as well as treatment studies that assess the impact of integrative therapies such as cognitive-behavioral therapy, yoga, and acupuncture on pain-related outcomes in adults with chronic pain. The research group is also working in the area of predicting and preventing misuse of opioids by patients with persistent pain. Psychosocial processes such as catastrophizing and negative affect are strongly associated with opioid misuse, and cognitive-behavioral interventions appear to be effective in targeting these factors and enhancing compliance with recommended medication regimens. Collectively, the center hopes that these studies will illuminate some of the common mechanisms by which diverse non-pharmacologic therapies help to improve the quality of life for patients with chronic pain.
Funding: R21 DA041020: Opioid-induced changes in pain modulation; PCORI: A Comparative Effectiveness Randomized Controlled Trial of Mindfulness Meditation versus Cognitive Behavioral Therapy for Opioid-Treated Chronic Low Back Pain; R01AR064367: Brain mechanisms underlying CBT-related reductions in fibromyalgia
PI: Robert R. Edwards, Ph.D.
Email: rredwards@partners.org
Web page: http://research.bwhanesthesia.org/research-groups/prc/clinical/edwards
Selected Publications:
- Distress Intolerance and Prescription Opioid Misuse Among Patients With Chronic Pain. McHugh RK, Weiss RD, Cornelius M, Martel MO, Jamison RN, Edwards RR. J Pain. 2016 Jul;17(7):806-14.
- Changes in Pain Sensitivity and Pain Modulation During Oral Opioid Treatment: The Impact of Negative Affect. Edwards RR, Dolman AJ, Michna E, Katz JN, Nedeljkovic SS, Janfaza D, Isaac Z, Martel MO, Jamison RN, Wasan AD. Pain Med. 2016 Oct;17(10):1882-1891.
- The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain. Edwards RR, Dworkin RH, Sullivan MD, Turk DC, Wasan AD. J Pain. 2016 Sep;17(9 Suppl):T70-92.
- Effects of Cognitive-Behavioral Therapy (CBT) on Brain Connectivity Supporting Catastrophizing in Fibromyalgia. Lazaridou A, Kim J, Cahalan CM, Loggia ML, Franceschelli O, Berna C, Schur P, Napadow V, Edwards RR. Clin J Pain. 2017 Mar;33(3):215-221.
- The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients. Loggia ML, Berna C, Kim J, Cahalan CM, Martel MO, Gollub RL, Wasan AD, Napadow V, Edwards RR. J Pain. 2015 Aug;16(8):692-9.
- The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction. Kim J, Loggia ML, Cahalan CM, Harris RE, Beissner F, Garcia RG, Kim H, Barbieri R, Wasan AD, Edwards RR, Napadow V. Arthritis Rheumatol. 2015 May;67(5):1395-405.
- Distraction analgesia in chronic pain patients: the impact of catastrophizing. Schreiber KL, Campbell C, Martel MO, Greenbaum S, Wasan AD, Borsook D, Jamison RN, Edwards RR. Anesthesiology. 2014 Dec;121(6):1292-301.
Center for Perioperative Genomics
The research programs within the Center are focused on exploring the genetic inputs into functional and structural heart disease, with a special focus on the perioperative environment. The Center is the over-arching structure for large-scale genetic studies that includes data and tissue resources for Investigators.
Current programs within the center include:
- The CABG Genomics Program, a two-institution study that provides patient data and genomics resources to the investigators. Since 2001, ~2,900 patients undergoing cardiac surgery have enrolled in the Program. Clinical data, patient outcomes, and DNA, buffy coat mRNA, plasma, and serum, are collected and stored for subsequent genotyping and measurement of circulating biomarkers. Specifically, CABG Genomics seeks to identify the relationships between genetic variation and major adverse cardiac events, bleeding and other patient outcomes after CABG surgery.
- The International Bicuspid Aortic Valve Consortium, a 26 institution consortium investigating the genetic etiology of bicuspid aortic valve disease. The consortium was started in 2011 and encompasses investigators from Europe, Canada and the U.S. The goals are to elucidate the genetic pathways involved in BAV etiology and the subsequent progression of aortic valve calcification by identifying genetic etiologies of BAV.
- The TRANSCRIBE study (Transcriptomic Analysis of Left Ventricular Gene Expression) aims to identify the genes expressed in response to acute myocardial ischemia, and the genetic modifiers of such gene expression.
Funding: R01HL098601 - Identification of genetic and molecular mechanisms of atrial fibrillation; R01HL114823 - Genetic etiology of bicuspid aortic valve disease; R01HL118266 - Genetics of gene expression in human left ventricular myocardium
PI’s: Simon Body, M.B.Ch.B., M.P.H. & J. Daniel Muehlschlegel, M.D., M.M.Sc.
Emails: sbody@partners.org & jmuehlschlegel@partners.org
Web page: http://research.bwhanesthesia.org/research-groups/cpg
Selected Publications:
- Sigurdsson MI, Muehlschlegel JD, Fox AA, Heydarpour M, Lichtner P, Meitinger T, Collard CD, Shernan SK, Body SC. Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery. J Cardiothorac Vasc Anesth. 2015;29(3):605-10.
- Saddic L, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia. Cardiovasc Diabetol. 2017 Jul 7;16(1):87. PMID: 28687077
- Sigurdsson MI Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper G, Shernan S, Muehlschlegel JD, Body SC. Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue. BMC Med Genomics. 2017 May 2;10(1):25. PMID: 28464817
- Saddic L, Sigurdsson MI, Chang TW, Mazaika E, Heydarpour M, Shernan SK, Seidman C, Seidman JG, Aranki SF, Body SC, Muehlschlegel JD. The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle. Circulation: Cardiovascular Genetics. 2017; Jan;10(1). PMID: 28115490
- Habchi KM, Ashikhmina E, Montiero Vieira V, Isselbacher EM, Sundt TM, Shekar P, Muehlschlegel JD, Body SC. Association Between Bicuspid Aortic Valve Morphotype and Regional Dilatation of the Aortic Root and Trunk. Int J Cardiovasc Imaging. 2016 Nov 12. PMID: 27838896
- Michelena HI, Prakash SK, Della Corte A, Bissell MM, Anavekar N, Mathieu P, Bossé Y, Limongelli G, Bossone E, Benson DW, Lancellotti P, Isselbacher EM, Enriquez-Sarano M, Sundt TM 3rd, Pibarot P, Evangelista A, Milewicz DM, Body SC; BAVCon Investigators. Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon).. Circulation. 2014 Jun 24;129(25):2691-704.
Aging Neuroscience Laboratory
The Laboratory for Aging Neuroscience is focused on the aging brain and the role of baseline cognitive impairment, surgery and anesthesia in the development of postoperative delirium and postoperative cognitive dysfunction; two very a common and distressing source of postoperative morbidity in the elderly. To do so we use rodent models to study the molecular changes in the brain after surgery and anesthesia and preoperative and intraoperative variables in older surgical patients that may be associated with adverse outcomes.
Whether there is a relationship between the enduring cellular and molecular effects of general anesthesia in the aged brain and the postoperative cognitive morbidity observed commonly in elders after surgery and anesthesia remains to be determined but we have established collaborations with colleagues in geriatrics, neurology, psychiatry and inflammation to begin to address that question. Our hope is that better understanding of the impact of preoperative and perioperative variables on the neurobiology of the aged brain will ultimately translate into improved cognitive outcome after surgery and anesthesia in elders.
Funding: RO1AG048522 – Microglial mechanisms of postoperative CNS inflammation and cognitive decline; R21AG048522 - Preoperative cognitive screening in elderly surgical patients: feasibility and utility for predicting morbidity
PI’s: Gregory Crosby, M.D., M.S.A. & Deborah J. Culley, M.D.
Emails: gjcrosby@bwh.harvard.edu & dculley@bwh.harvard.edu
Web page: http://research.bwhanesthesia.org/research-groups/lan
Selected Publications:
- Culley DJ, Flaherty D, Fahey MC, Rudolph JL, Houman J, Wright JR, Bader AM, Hyman BT, Blacker D, Crosby G. Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients. Anesthesiology, 2017, In Press.
- Culley DJ, Flaherty D, Reddy S, Fahey MC, Rudolph JL, Huang CC, Liu X, Xie Z, Bader AM, Hyman BT, Blacker D, Crosby G., Preoperative Cognitive Stratification of Older Elective Surgical Patients, Anesth Analg. 2016 Jul;123(1):186-92
Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G. Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. Front Aging Neurosci. 2014 Jun 10;6:107.
- Culley DJ, Cotran EK, Karlsson E, Palanisamy A, Boyd JD, Xie Z, Crosby G. Isoflurane Affects the Cytoskeleton But Not Survival, Proliferation, or Synaptogenic Properties of Astrocytes InVitro. British Journal of Anaesthesiology, 2013, 110 (S1):i19-i28.
- Culley DJ, Baxter MG, Yukhananov RY, Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology 2004, 100:309-14.
- Culley DJ, Yukhananov RY, Xie Z, Galli R, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in aged rats. European Journal of Pharmacology. 2006, 549(1-3):71-8.
Laboratory of Nanomedicine and Biomaterials
Research in the Laboratory of Nanomedicine and Biomaterials is focused on the development of novel nanotechnologies for medical applications. The team has pioneered design, engineering, and high throughput screening of multifunctional nanoparticle technologies for the treatment of cancers, inflammatory and immunological diseases. The targeted nanoparticle for the treatment of solid tumors, BIND-014, is in Phase II human clinical trials (ClinicalTrials.gov Identifiers: NCT01792479 and NCT01812746), marking the first-in-human testing of a targeted polymeric nanoparticle for cancer chemotherapy. A nicotine nanoparticle vaccine, SEL-068, has also entered the clinical trials for smoking cessation and relapse prevention, and the clinical translation of SEL-068 marked the first-in-human testing of targeted polymeric nanoparticle vaccine (ClinicalTrials.gov Identifier: NCT01478893).
Over the past 12 years, research in the Farokhzad laboratory has sought to develop robust engineering processes to accelerate translation of nanotherapeutics for clinical applications. At the same time, the team has advanced our fundamental understanding of the interface between nanomaterials and the biological system, all in order to aid in nanoparticle drug development. Currently, Dr. Farokhzad’s group has 11 postdoctoral fellows and visiting scientists, and 17 research assistants and technicians.
Funding: R01EB015419 - Development of FCRN-targeted nanoparticles for efficient oral delivery of insulin
PI: Omid C. Farokhzad, M.D., M.A., M.B.A.
Email: ofarokhzad@bwh.harvard.edu
Web page: http://farokhzad.bwh.harvard.edu
Selected Publications:
- Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chem Rev. 2015; 10:759-776. (Impact factor = 46.5)
- Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittel MJ, Farokhzad OC* Weissleder R*. Sci Transl Med.2015; 7:314ra183. (*=corresponding author)
- Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perrtti M, Farokhzad O*, Tabas I*. Targeted nanoparticles containing the proresolving peptide Ac2-2 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med.2015; 7:275ra20. (*=corresponding author).
- Farokhzad OC. Nanotechnology: Platelet mimicry. Nature 2015; 526:47-48.
- Kamaly N, He JC, Ausiello DA, Farokhzd OC. Nanomedicine for renal disease: current status and future applications. Nature Review Nephrology. 2016; 12:738-753
- Shi J, Kantoff PW, Wooster R, Farokhzd OC. Cancer nanomedicine: progress, challenges and opportunities. Nature Review Cancer. 2017; 17:20-37.
- Mahmoudi M, Yu M, Serphooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyapathy. Nature Nanotechnology. 2017; in-press
- Bertrand M, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim J-M, Karnik R, Langer R, Farokhzd OC. Mechanistic understanding of in vivo protein corona on polymeric nanoparticles and impact on pharmacokinetics. Nature Communication. 2017; in-press
Brian Bateman / Division of Pharmacoepidemiology and Pharmacoeconomics
Brian Bateman’s research focuses on pharmacoepidemiology in pregnancy and the epidemiology of pregnancy related complications. His research is primarily conducted within the Division of Pharmacoepidemiology and is done in close collaboration with Krista Huybrechts and Sonia Hernandez-Diaz (from the Harvard School of Public Health). Topics of primary interest include the use of opioids during pregnancy and its consequences, the safety of cardiovascular medications in pregnancy, predictors of severe maternal morbidity and mortality, and medication safety in the perioperative period.
Funding: RO1 DA044293 - The impact of prescription opioid use on pregnancy outcomes, K08HD075831 - Comparative safety & effectiveness of antihypertensive medications in pregnancy, Lilly, Pfizer, Pacira, GSK
PI: Brian Bateman, M.D., M.Sc.
Email: BBateman@bwh.harvard.edu
Web page: http://www.drugepi.org/faculty-staff-trainees/faculty/brian-bateman/
Selected Publications:
- Bateman BT, Cole NM, Maeda A, Burns SM, Houle TT, Huybrechts KF, Clancy CR, Hopp SB, Ecker JL, Ende H, Grewe K, Raposo Corradini B, Schoenfeld RE, Sankar K, Day LJ, Harris L, Booth JL, Flood P, Bauer ME, Tsen LC, Landau R, Leffert LR. Patterns of Opioid Prescription and Use After Cesarean Delivery. Obstet Gynecol. 2017 Jun 6.
- Prabhu M, McQuaid-Hanson E, Hopp S, Burns SM, Leffert LR, Landau R, Lauffenburger JC, Choudhry NK, Kaimal A, Bateman BT. A Shared Decision-Making Intervention to Guide Opioid Prescribing After Cesarean Delivery. Obstet Gynecol. 2017 Jun 6.
- Bateman BT, Patorno E, Desai RJ, Seely EW, Mogun H, Maeda A, Fischer MA, Hernandez-Diaz S, Huybrechts KF. Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia. Pediatrics. 2016 Sep;138(3). pii: e20160731
- Oberg AS, D’Onofrio BM, Rickert ME, Hernandez-Diaz S, Ecker JL, Almqvist C, Larsson H, Lichtenstein P, Bateman BT. Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. JAMA Pediatr. 2016 Sep 6;170(9):e160965.
- Baker JA, Avorn J, Levin R, Bateman BT. Opioid Prescribing After Surgical Extraction of Teeth in Medicaid Patients, 2000-2010. JAMA. 2016 Apr 19;315(15):1653-4.
- Bateman BT, Hernandez-Diaz S, Fischer MA, Seely EW, Ecker JL, Franklin JM, Desai RJ, Allen-Coleman C, Mogun H, Avorn J, Huybrechts KF. Statins and Congenital Malformations: A Cohort Study. BMJ. 2015 Mar 17;350:h1035
- Huybrechts KF, Bateman BT, Palmsten K, Patorno E, Desai R, Levin R, Mogun H, Hernandez-Diaz S. Antidepressant Use Late in Pregnancy and Risk of Persistent Pulmonary Hypertension of the Newborn. JAMA 2015 Jun 2;313(21):2142-51
- Desai RJ, Huybrechts KF, Hernandez-Diaz S, Mogun H, Patorno E, Kaltenbach K, Kerzner LS, Bateman BT Exposure to prescription opioid analgesics in-utero and the risk of neonatal abstinence syndrome: A population-based cohort study. BMJ 2015 May 14;350:h2102
- Patorno E, Neumann MD, Schneeweiss S, Mogun H, Bateman BT. Comparative safety of anesthetic technique for hip fracture surgery in adults. BMJ. 2014 Jun 27;348:g4022.
- Oberg AS, Hernandéz-Diaź S, Frisell T, Greene MF, Almqvist C, Bateman BT. Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466 686 births. BMJ. 2014 Aug 13;349:g4984
- Bateman BT, Bykov K, Choudhry NK, Schneeweiss S, Gagne JJ, Polinski JM, Franklin JM, Doherty M, Fischer MA, Rassen JA. Type of stress ulcer prophylaxis and the risk of nosocomial pneumonia in cardiac surgical patients: a cohort study. BMJ. 2013 Sep 19;347:f5416
Center for Perioperative Research (C.P.R.)
The mission of the Center for Perioperative Research is to facilitate research projects designed to test strategies that promote high quality perioperative care. We created a unique and innovative collaborative model of clinical and translational research led by Surgeon-Anesthesiologist teams designed to improve quality of perioperative care, realize cost savings, and foster education of the members of Surgery and Anesthesia Departments. Our research activities include clinical trials of pharmaceutical agents, monitoring, and equipment. Other recent projects have focused on understanding clinical risk factors for post-discharge surgical readmissions and reoperations using hospital and national outcomes data. Some of the projects involve investigation of the efficacy of informatics-based clinical decision tools, efficacy of perioperative (OR and Non-OR) efficiency interventions, and enhanced recovery after surgery (ERAS) pathways. We have performed analysis of quality metrics and patient outcomes using national databases to study patient mortality, care patterns, complication rates, and healthcare utilization. Recent work has focused on outcomes data from NSQIP, NIS, Medicare/Medicaid, NACOR and closed claims databases. Our recent patient safety-related research has been focused on emergency manuals, including a recent multi-institutional study funded by the Anesthesia Patient Safety Foundation. There is also an ongoing study on the preoperative goals of care discussions funded by the Foundation for Anesthesia Education and Research. The Center is currently working on a collaborative project with the medicine department to identify risk factors for opioid-related complications in hospitalized surgical patients.
Funding: Anesthesia Patient Safety Foundation; Foundation for Anesthesia Education and Research; Merck; Mallinckrodt; Medtronic
PI: Richard D. Urman, M.D., M.B.A., F.A.S.A. (Anesthesia), Co-Director: Edward E Whang, M.D., F.A.C.S. (Surgery)
Email: rurman@bwh.harvard.edu
Web page: http://www.brighamandwomens.org/Departments_and_Services/anesthesiology/services/cpmmi.aspx
Selected Publications:
- Helander EM, Webb MP, Bias M, Whang EE, Kaye AD, Urman RD. A comparison of multimodal analgesia approaches in institutional ERAS protocols for colorectal surgery: pharmacological agents. J Laparoendosc Adv Surg Tech 2017 Jul 25 [Epub ahead of print].
- Nagrebetsky A, Gabriel RA, Dutton RP, Urman RD. Growth of nonoperating room anesthesia care in the United States: a contemporary trends analysis. Anesth Analg 2017 Apr;124(4):1261-1267.
- Lyu HG, Sharma G, Brovman E, Ejiofor J, Repaka A, Urman RD, Gold J, Whang EE. Risk factors of reoperation after pancreatic resection. Dig Dis Sci, 2017 Mar 24.
- Juang J, Gabriel RA, Dutton RP, Palanisamy A, Urman RD. Choice of anesthesia for cesarean delivery: an analysis of the National Anesthesia Clinical Outcomes Registry. Anesth Analg 2017 Jun;124(6):1914-1917.
- Quinn TD, Brovman EY, Aglio L, Urman RD. Factors associated with an increased risk of perioperative cardiac arrest in emergent and elective craniotomy and spine surgery. Clin Neurol Neurosurg 2017 Jul 25;161:6-13.
- Beverly A, Brovman EY, Malapero RJ, Lekowski RW, Urman RD. Unplanned reintubation following cardiac surgery: incidence, timing, risk factors and outcomes. J. Cardiothoracic Vasc Anesth 2016;30(6):