Loma Linda University

The Department of Anesthesiology and Loma Linda University Medical Center has a very active research division with many ongoing clinical and basic science projects. Reach within the department is geared with a single purpose in mind, to improve patient outcomes. Many opportunities for neuroscience research are available in the Zhang Neuroscience Laboratory, which is housed in the Anesthesiology Department. The Zhang lab has NIH P01 program grant funding to study hemorrhagic stroke, and many R01 grants for studies of methods to improve outcome following ischemic stroke, global cerebral ischemia including hypoxia-ischemia, neonatal hypoxia, surgical brain injury (edema and bleeding) and cardiac arrest. Many of these projects have translation components that are actively being implemented. In addition the department works closely with the Center for Perinatal Biology on topic of vascular reactivity.

Clinical research focuses on: the utility of ultrasound in medicine, medical technology development, hemodynamic monitoring, coagulation disorders, innovation in laboratory testing, medical education, perioperative medicine and care coordination development. Clinical research is focused not only improving perioperative care but also demonstrating the utility of collaboration across multiple patient care settings. The department has also developed a perioperative hospitalist service that strives to educate residents on the continuum of perioperative care and facilitate medical management and coordination of care of postsurgical patients.

For 2016, the clinical faculty produced over 30 publications and the basic research division produced over 40 publications. An overview of recent topics are below:

Medical Ultrasound:

Hemodynamic Monitoring:

Blood Disorders and Coagulation:

Pediatric Anesthesia Research:

Educational Research:

Perioperative Medicine and Coordinated Patient Care:

Neuroscience:

Snake venom pretreatment to prevent surgical brain injury: The potential benefit of pretreatment with a variety of snake venoms in studies of surgical bleeding and post-surgery edema is promising. A number of projects are underway that involve department members and trainees. These projects are supported by an R01 NIH Grant (“Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury”).

Neurologic function after cardiac arrest: Interventions to improve neurologic outcome following cardiac arrest are being studied using a rat model of sudden cardiac arrest and resuscitation by researcher Dr. Lei Helen Huang. Working with other members of the Zhang lab this study of post-resuscitation interventions could provide treatments to improve outcome after cardiac arrest. This work is partially supported by a $25,000 grant from the Floyd S. Brauer Anesthesiology.

Research Endowment:

Program Project Grant:

Program Project Grant to establish the Center for Brain Hemorrhage Research: $7.7 million NIH award to the Zhang Neuroscience Laboratories. We anticipate a number of important findings to come from this Center. It is our hope that based on results from basic science projects we will be able to carry out translational research on interventions that show promise to improve outcomes after hemorrhagic stroke.