Weill Cornell Medicine

Research at Weill Cornell is richly enhanced by its existence within an extraordinary multi-institutional academic environment, that also includes Rockefeller University, Memorial Sloan-Kettering Cancer Center, the Hospital for Special Surgery, and Cornell Tech. Weill Cornell Anesthesiology residents have conducted research with investigators at all these institutions.

BASIC SCIENCE RESEARCH:

Simon Scheuring, PhD

The Bio-AFM Lab performs atomic force microscopy (AFM) based research of biological samples, with a particular interest in membrane phenomena. The technique elucidates the structure, dynamics, diffusion, interaction, mechanics and supramolecular assembly of membrane proteins and other membrane constituents.

Ruan Y, Miyagi A, Wang X, Chami M, Boudker O, Scheuring S. 2017. Direct visualization of glutamate transporter elevator mechanism by high-speed AFM.. Proc Natl Acad Sci U S A. 114(7):1584-1588.

Mierzwa BE, Chiaruttini N, Redondo-Morata L, von Filseck JMoser, König J, Larios J, Poser I, Müller-Reichert T, Scheuring S, Roux A et al.. 2017. Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis.. Nat Cell Biol. 19(7):787-798.

Crina Nimigean, PhD

Research in the Nimigean Laboratory is geared toward understanding how ion channel protein structure and mechanism interrelate at the molecular level to allow channels to elaborate various biological properties. We use a combination of molecular, biochemical and electrophysiological approaches to evaluate in a complete fashion fundamental channel properties within the context of emerging structural data.

Menny A, Lefebvre SN, Schmidpeter PAm, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer P-J. 2017. Identification of a pre-active conformation of a pentameric channel receptor.. Elife. 6

Kim DM, Dikiy I, Upadhyay V, Posson DJ, Eliezer D, Nimigean CM. 2016. Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.. J Gen Physiol. 148(2):119-32.

Kim DM, Nimigean CM. 2016. Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.. Cold Spring Harb Perspect Biol. 8(5)

Rangl M, Miyagi A, Kowal J, Stahlberg H, Nimigean CM, Scheuring S. 2016. Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.. Nat Commun. 7:12789.

Alessio Accardi, PhD

Work in the Accardi lab is aimed at uncovering the molecular and structural underpinnings regulating the movement of charged ions across cellular membranes. This process results in the electrical currents underlying scores of fundamental physiological processes such as the neuronal action potential, muscle contraction, insulin secretion and signal transduction. In the lab, we use a combination of techniques to study this phenomenon, ranging from X-ray crystallography, to single channel and macroscopic current electrophysiology, calorimetry, reconstitution into synthetic lipid bilayers and other biochemical assays.

Vien M, Basilio D, Leisle L, Accardi A. 2017. Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger.. J Gen Physiol. 149(4):523-529.

Lee B-C, Menon AK, Accardi A. 2016. The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.. Biophys J. 111(9):1919-1924.

Siesto G, Romano F, Accardi A, Bulletti C, Iedà NPalma, Vitobello D. 2016. Robotic Surgery in Patients With Locally Advanced Cervical Cancer After Neoadjuvant Chemotherapy: Survival Outcomes.. Int J Gynecol Cancer. 26(3):521-7.

Peter Goldstein, MD

The overall focus of the lab is to better define the mechanisms by which a diverse group of pharmacological agents produce anesthesia. A potentially important region within the CNS for contributing to the anesthetized state is the thalamus. What are the effects of different anesthetics on synaptic transmission in the thalamus? GABA release is controlled by multiple mechanisms, including a variety of ion channels; is the function of those channels altered in the presence of anesthetics? The lab uses electrophysiological, immunohistochemical, and molecular biological techniques to address those issues.

Inan M, Zhao M, Manuszak M, Karakaya C, Rajadhyaksha AM, Pickel VM, Schwartz TH, Goldstein PA, Manfredi G. 2016. Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.. Neurobiol Dis. 93:35-46.

Steinbeck JA, Jaiswal MK, Calder EL, Kishinevsky S, Weishaupt A, Toyka KV, Goldstein PA, Studer L. 2016. Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease.. Cell Stem Cell. 18(1):134-43.

Heuermann RJ, Jaramillo TC, Ying S-W, Suter BA, Lyman KA, Han Y, Lewis AS, Hampton TG, Shepherd GMG, Goldstein PA et al.. 2016. Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.. Neurobiol Dis. 85:81-92.

Tibbs GR, Posson DJ, Goldstein PA. 2016. Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? Trends Pharmacol Sci. 37(7):522-42.

Paul Riegelhaupt, MD, PhD

Work in the Riegelhaupt Lab focuses on a specific family of ion channels that are responsible for setting the resting membrane potential, the tandem pore potassium (K2P) channels. The research aims to address fundamental questions regarding the gating and regulation of K2P's by means of structural and electrophysiologic approaches. The importance of K2P channels has been demonstrated in numerous research areas such as pain biology, glucose homeostasis, ischemic preconditioning, and control of smooth muscle tone, and studies of K2P physiology and pharmacology promise to yield advances in these and other areas.

Riegelhaupt PM, Hemmings HC, Goldstein PA. 2016. Relevance of Clinical Relevance.. Anesthesiology. 125(4):821-2.

Hugh Hemmings Jr, MD, PhD

In the Hemmings laboratory, the effects of general anesthetics on neurotransmitter release (e.g., glutamate, GABA, dopamine, norepinephrine, neuropeptides) and on their interactions between specific presynaptic proteins involved in the control of neurotransmitter release (ion channels, SNAREs) are being studied at the behavioral, network, cellular and molecular levels in animal models, cultured cells and neurons, brain slices, isolated nerve terminals and using purified recombinant proteins. Techniques include biochemical, imaging, and electrophysiological approaches.

Herold KF, R Sanford L, Lee W, Andersen OS, Hemmings HC. 2017. Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.. Proc Natl Acad Sci U S A.

Herold KF, Andersen OS, Hemmings HC. 2017. Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.. Eur Biophys J.

Hemmings HC. 2017. A global vision for the British Journal of Anaesthesia.. Br J Anaesth. 118(1):1-2.

Sand RM, Gingrich KJ, Macharadze T, Herold KF, Hemmings HC. 2017. Isoflurane modulates activation and inactivation gating of the prokaryotic Na(+) channel NaChBac.. J Gen Physiol. 149(6):623-638.

Hara M, Zhou Z-Y, Hemmings HC. 2016. α2-Adrenergic Receptor and Isoflurane Modulation of Presynaptic Ca2+ Influx and Exocytosis in Hippocampal Neurons.. Anesthesiology.

Jimcy Platholi, PhD

Dr. Platholi investigates the effects of isoflurane on morphology and stability of dendritic spines, a structure critical for synaptic plasticity. We show that a clinically relevant concentration and duration of isoflurane results in transient reductions in spine area and spine number, and that these changes are mediated by destabilization of the underlying actin cytoskeleton. These findings implicate dendritic spines as a pharmacological substrate for the synaptic actions of isoflurane. Actin filament destabilization provides a molecular and structural basis for anesthetic effects on synaptic transmission and function consistent with emerging concepts of synaptic plasticity.

Johnson KW, Herold KF, Milner TA, Hemmings HC Jr, Platholi J.

Johnson KW, Herold KF, Milner TA, Hemmings HC Jr, Platholi J. 2017. Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus. J Comp Neurol. 525(16):3563-3578.

Paola Calderon, MD, PhD

Working with the Pfaff Lab at Rockefeller University, using in vivo recordings from cortex, thalamus and lower brainstem, Dr. Calderon discovered that the brain undergoes a set of abrupt transitions between several spatiotemporal patterns of activity while emerging from general anesthesia. New work with Nicholas Schiff and Esteban Fridman in the Feil Family Brain and Mind Research Institute focuses on dopaminergic deficit across post-traumatic minimally conscious state patients when using molecular neuroimaging to measure D2-like receptor occupancy and response to transient pharmacological manipulations.

Calderon DP, Kilinc M, Maritan A, Banavar JR, Pfaff D. 2016. Generalized CNS arousal: An elementary force within the vertebrate nervous system.. Neurosci Biobehav Rev. 68:167-76.

Kane Pryor, MD

Dr. Pryor studies how anesthetic drugs affect the memory and emotional systems of the human brain. Because anesthetics have such a remarkable effect on human memory, careful study of the mechanisms of these drugs can provide critical insight into how human memory functions work. This research involves the use of fMRI, EEG, and neurophysiology techniques.

Hudson AE, Pryor KO. 2016. Integration and Information: Anesthetic Unconsciousness Finds a New Bandwidth. Anesthesiology. 125(5):832-834.

Pryor KO, Veselis RA. 2016. Isolated Forearm Test: Replicated, Relevant, and Unexplained. Anesthesiology.

Kingsley Storer, MD, PhD

Dr. Storer’s major interest is in study of the mechanisms of propofol induced loss of consciousness and amnesia. He is using computational modeling of a thalamocortical neural network to investigate how propofol affects cortical connectivity. Other work involves the study of gamma and theta rhythms in a hippocampal neural network to shed more light on how propofol prevents memory formation.

Anesthesiology Trials Group

Kane Pryor, MD, Director

The Anesthesiology Trials Group is internationally recognized for the rigorous conduct of multi-national, multi-institutional clinical trials, and works with multiple trial networks and consortiums based in the United States, Europe, and Australasia. All Weill Cornell Residents will have contact with these trials through enrolled patients. The expertise and resources of the trials unit — which includes statisticians, methodologists, programmers, research managers, and assistants — are also available to residents wishing to engage in smaller, single-institution studies.

Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, Veselis RA, Grocott HP, Emmert DA, Rogers EM, Downey RJ, Yulico H, Noh GJ, Lee YH, Waszynski CM, Arya VK, Pagel PS, Hudetz JA, Muench MR, Fritz BA, Waberski W, Inouye SK, Mashour GA; PODCAST Research Group. 2017 Jul 15. Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet. 390(10091):267-275.

Shaparin N, Mehta N, Kunkel F, Stripp R, Borg D, Kolb E. 2017. A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid.. Pain Med.

Witkin LR, Zylberger D, Mehta N, Hindenlang M, Johnson C, Kean J, Horn SD, Inturrisi CE. 2017. Patient-Reported Outcomes and Opioid Use in Outpatients With Chronic Pain.. J Pain.

Rong LQia. 2017. An update on intraoperative three-dimensional transesophageal echocardiography.. J Thorac Dis. 9(Suppl 4):S271-S282.

Heerdt PM, Sunaga H, Owen JS, Murrell MT, Malhotra JK, Godfrey D, Steinkamp M, Savard P, Savarese JJ, Lien CA. 2016. Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man.. Anesthesiology. 125(6):1136-1143.

Berger MM, Macholz F, Tangel V, Pryor KO. 2016. Effect of intraoperative high oxygen concentrations on surgical site infection.. J Hosp Infect. 94(2):206-7.

Mehta N, O'Connell K, Giambrone GP, Baqai A, Diwan S. 2016. Efficacy of methylnaltrexone for the treatment of opiod-induced constipation: a meta-analysis and systematic review.. Postgrad Med. :1-8.

Chen Y, Pryor KO, Avidan MS. 2016. In Response.. Anesth Analg. 123(6):1639.

Mehta N, Zocca J, Shaparin N, Snyder M, Singh JR. 2016. Intravenous Conscious Sedation for Routine Fluoroscopically Guided Lumbar Interventions.. PM R. 8(4):373-9.

Perlman J, Kjaer K. 2016. Neonatal and Maternal Temperature Regulation During and After Delivery.. Anesth Analg. 123(1):168-72.

Cea ME, M Reid C, Inturrisi C, Witkin LR, Prigerson HG, Bao Y. 2016. Pain Assessment, Management, and Control Among Patients 65 Years or Older Receiving Hospice Care in the U.S.. J Pain Symptom Manage. 52(5):663-672.

Sunaga H, Savarese JJ, McGilvra JD, Heerdt PM, Belmont MR, Van Ornum SG, Murrell MT, Malhotra JK, Savard PM, Jeannotte E et al.. 2016. Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat.. Anesthesiology. 125(4):732-743.

Aaronson J, Abramovitz S, Smiley R, Tangel V, Landau R. 2016. A Survey of Intravenous Remifentanil Use for Labor Analgesia at Academic Medical Centers in the United States.. Anesth Analg.

Chiao FB, Wang A. 2017. An Examination of Disparities in Pediatric Pain Management Centered on Socioeconomic Factors and Hospital Characteristics.. J Racial Ethn Health Disparities.

The Center for Perioperative Outcomes

Zachary Turnbull, MD, Director

The Center for Perioperative Outcomes (CPO) is a division of Weill Cornell Anesthesiology dedicated to large-scale database research. The CPO partners with the Architecture for Research Computing in Health (ARCH) division of the Department of Research Computing, and has created a Research Data Repository (RDR) to house pre-, intra-, and post-operative data in a single location. The CPO also is a repository for massive-scale government and consortium databases, and heads the department’s participation in the Multicenter Perioperative Outcomes Group (MPOG). The CPO also engages in information technology operations innovation and development. Residents and fellows working with the CPO benefit from the available expertise in coding, statistics, and methodology, and are highly productive academically. Multiple residents from Weill Cornell have won awards for their CPO work.

Turnbull ZA, Sastow D, Giambrone GP, Tedore T. 2017. Anesthesia for the patient undergoing total knee replacement: current status and future prospects.. Local Reg Anesth. 10:1-7.

Xu HF, White RS, Sastow DL, Andreae MH, Gaber-Baylis LK, Turnbull ZA. 2017. Medicaid insurance as primary payer predicts increased mortality after total hip replacement in the state inpatient databases of California, Florida and New York.. J Clin Anesth. 43:24-32.

Stiles BM, Poon A, Giambrone GP, Gaber-Baylis LK, Wu X, Lee PC, Port JL, Paul S, Bhat AU, Zabih R et al.. 2016. Incidence and Factors Associated With Hospital Readmission After Pulmonary Lobectomy.. Ann Thorac Surg. 101(2):434-43.

Fleischut PM, Eskreis-Winkler JM, Gaber-Baylis LK, Giambrone GP, Wu X, Sun X, Lien CA, Faggiani SL, Dutton RP, Memtsoudis SG. 2016. Provider Board Certification Status and Practice Patterns in Total Knee Arthroplasty.. Acad Med. 91(1):79-86.

Giambrone GP, Smith MC, Wu X, Gaber-Baylis LK, Bhat AU, Zabih R, Altorki NK, Fleischut PM, Stiles BM. 2016. Variability in length of stay after uncomplicated pulmonary lobectomy: is length of stay a quality metric or a patient metric?†. Eur J Cardiothorac Surg. 49(4):e65-71.

Quality and Patient Safety Division

Patricia Mack, MD, QPS Director

The Quality and Patient Safety (QPS) Division offers many opportunities for residents to gain firsthand experience improving healthcare systems to advance patient safety. Equipped with a foundation in quality improvement methodology and guidance from faulty mentors and the QPS division, residents can identify areas for improvement and work collaboratively with others in the department and throughout the hospital to effect change. In addition, residents participate in didactic and experiential learning to improve their understanding of principles of patient safety, including significant event investigation and root cause analysis.